Taking Xanax in the background of alcohol intoxication is undesirable, since the risk of developing drug dependence increases significantly. Cases of deaths have been reported among people whose blood alcohol content was always below normal, which leads to fatal poisoning after taking the drug. The combination of taking the drug with alcohol can lead to sudden pressure drops, chills, vomiting, blood clotting disorders, hemorrhages, heart attacks, problems with cerebral circulation.
The initial dose of Xanax tranquilizer is prescribed at the dosage of 250-500 mcg three times a day. The increase should not exceed 4.5 mg / day with clear agreement with the doctor. The initial dose of the drug with a hypnotic effect for elderly or sickly and weak patients is no more than 250 mcg two or three times a day, and the maintenance dose of alprazolam is 500-750 mcg per day. Discontinuation of intake and reduction of dosage should be done gradually, reducing the dose no more than 500 mcg once every three days or even more slowly.
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Xanax is very strong, so it can easily lead to an overdose. The patient will experience drowsiness, confusion, ataxia, nausea, vomiting. Complex cases are characterized by a decrease in reflexes, up to the advent of commas. The patient should perform gastric lavage and take (activated carbons) to relieve negative symptoms, Norepinephrine is injected in case of hypotension.
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- Anxiety, social phobia, various fears can easily become companions of a modern person whose psyche is subjected to constant stress in conditions of multiple information flows. In this situation, Xanax (one of the forms of benzodiazepines) will come to the rescue. Its common property is the ability to slow down the excitation of the nervous system. Being a psychoactive substance, it begins to act quickly, having a calming effect on the body. The drug requires careful use, as it can be dangerous when combined with other drugs.
- Xanax has a very high potential of action: 1 mg is equivalent to 1 g of Valium. The drug has anxiolytic (elimination of anxiety) and muscle relaxant (reduction of muscle tension) effects. The drug activates the receptors involved in the perception of sedatives, helps to slow down nerve impulses through the release of gamma-aminobutyric acid, reduces anxiety. The drug is rapidly absorbed in the gastrointestinal tract, reaching its maximum concentration in the blood after an hour and a half.
- The drug belongs to tranquilizers, therefore, the reception should be carried out strictly taking into account the available direct indications and with the permission of a doctor. Self-medication can cause addiction, and the combination with other soothing drugs causes severe side effects. Cancellation or reduction of the dose of Xanax should be carried out gradually, reducing the daily dose by no more than 500 mcg every 3 days; sometimes even slower cancellation may be required.
- Xanax is taken with extreme caution in cases of impaired liver and kidney function, severe depression, suicidal mood, panic disorders. If you want to avoid withdrawal syndrome (withdrawal symptoms), treatment should be stopped gradually, reducing the dose by no more than 0.5 mg every 3 days. During treatment, it is not recommended to drive a car or operate other potentially dangerous mechanisms. Lactating women should give up breastfeeding for the period of admission.
- Xanax belongs to a group of antidepressants that relieve tension, neurosis, eliminate fears, depression. The drug was widely in demand for the treatment of the nervous system, but now its state registration period has expired, and it is very difficult to find the drug in pharmacies. You can read the instructions of the drug and learn about its characteristics, side effects, overdose.
- You should always think not only about the time during which the effect of Xanax lasts, but also about the effect of these pills on the body. After all, after the cancellation of Xanax, a person's anxiety increases very much, he/she begins to panic, becomes simply insane, harms himself/herself and others.
- Doctors recommend starting to take this drug with a minimum dose. If you take Xanax for the first time and you don't know how it will affect you, then it's better to take less, and then start taking larger doses gradually, if necessary.
-Large doses of Xanax can be fatal. It works for everyone, both for people who take it for the first time, and for those who have been taking it for several months or years according to the instructions of a doctor. You should not take a dose more than the one prescribed by the doctor.
- Large doses can lead to another unusual side effect. A person who takes Xanax begins to behave strangely. He/she can become aggressive and light-minded or start stealing someone else's things. It's not very clear why people behave this way, or how to predict that this will happen to you.
- Xanax is taken orally and quickly enters the bloodstream. Someone begins to feel the effects within 5-10 minutes after taking it. After an hour, almost everyone feels the effects. One of the reasons why Xanax is so effective for panic is that the peak effect comes quickly. Most people experience it within 1-2 hours after taking the drug.
- The half-life of Xanax is about 11 hours. By this time, half of the dose will have been eliminated from the body. However, the half-life is different for everyone because of the different metabolism of drugs. When Xanax is removed, the person will no longer feel calm and relaxed.
- You may take this drug to relieve symptoms of anxiety, for example, palpitations. However, these symptoms may return by the time the substance is removed. If you don't have them, you'll feel fine. A change in mood after Xanax is not the same as withdrawal. Many people do not feel a change in mood after taking the drug because it does not cause euphoria. Some people may experience feelings of depression and anxiety, even though they did not experience this before taking Xanax. It is the brain's reaction to the absence of the drug in the body. However, this side effect is temporary. Some people also note gaps in memory and loss of consciousness. Larger doses cause a stronger effect.
- Many people who take Xanax for pleasure describe its effect as soothing and soporific. Unlike some drugs such as cocaine, which cause a euphoric effect, the sensations from Xanax are more relaxing. These sensations can lead to several hours of sleep.
- It is recommended to take the minimum effective doses. The dose is corrected during treatment, depending on the effect achieved and tolerability. If it is necessary to increase the dose, it should be increased gradually, first in the evening and then in the afternoon. Experimental studies have shown that Xanax and its metabolites are excreted in breast milk.
- Xanax has a toxic effect on the fetus and increases the risk of developing birth defects when taken in the first trimester of pregnancy. Constant reception during pregnancy can lead to physical dependence with the development of withdrawal syndrome in a newborn. The reception of the drug in therapeutic doses in later pregnancy can cause depression of the newborn's central nervous system.
- Effective treatment of panic disorder often necessitates Xanax doses exceeding 4 mg/day. Controlled trials evaluating Xanax's efficacy in panic disorder utilized doses ranging from 1-10 mg/day.
- The average daily dosage in the panic disorder development program was approximately 5-6 mg, with around 300 patients receiving doses exceeding 7 mg/day, including approximately 100 patients taking over 9 mg/day. A subset required doses up to 10 mg/day for successful treatment.
- Patients receiving doses surpassing 4 mg/day should undergo periodic reassessment and consider dosage reduction. In post marketing studies, patients managed to halve their maintenance dose without compromising efficacy. Abrupt discontinuation should be avoided due to withdrawal risk.
- The recommended initial dose for anxiety patients is 0.25–0.5 mg three times daily, with gradual escalation every 3-4 days to a maximum daily dose of 4 mg, administered in divided doses. Regular reevaluation for continued treatment necessity is advised, considering the risk of dose-related addiction.
- Gradual dose reduction is essential upon discontinuation or dosage decrease. While no specific discontinuation schedule is universally endorsed, reducing the daily dose by no more than 0.5 mg every 3 days is generally recommended, with some patients requiring slower titration.
- Despite low concentrations of benzodiazepines, including alprazolam, in breast milk, breastfeeding is discouraged during Xanax treatment to optimize clinical outcomes. Alprazolam dosage should be tailored individually for each case.
- Benzodiazepine use during pregnancy poses fetal risks. Patients should be informed of potential hazards if they use Xanax during pregnancy or become pregnant while on treatment.
- Given the low urgency of Xanax use, its usage in the first trimester of pregnancy should be avoided whenever possible. Patients should be counseled on the importance of communicating pregnancy plans or status with their healthcare providers.
- Xanax is indicated for anxiety treatment or short-term symptom relief, typically corresponding to APA Diagnostic and Statistical Manual criteria. Routine stress or daily anxieties generally do not warrant anxiolytic therapy. Xanax is contraindicated in patients with known hypersensitivity to benzodiazepines. While open-angle glaucoma patients receiving appropriate treatment can use Xanax, it is contraindicated in acute narrow-angle glaucoma cases.